Synaptic Vesicle Dynamics
The laboratory investigates the fundamental aspects of synaptic vesicle recycling related to neurological and neurodegenerative diseases using mouse and mammalian cells as a model system. Cutting edge genomic engineering is combined with the latest imaging and cell biological techniques to study the processes that regulate synaptic vesicle formation. In a distinct but related strand of work, we are exploring the signaling processes that arise from altered neurotransmission and lead to neurodegeneration.
Selected recent publications:
Fernandez-Mosquera L, Yambire KY, Couto R, Pereyra L, Stagi M, Milosevic I, Raimundo N. (2018) Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis. (2018) Autophagy, in press
Watanabe S, Mamer LE, Raychaudhuri S, Luvsanjav D, Eisen J, Trimbuch T, Söhl-Kielczynski B, Fenske P, Milosevic I, Rosenmund C, Jorgensen EM (2018) Synaptojanin and endophilin mediate neck formation during ultrafast endocytosis. Neuron 98(6), 1184-1197
Farsi Z, Gowrisankaran S, Matija K, Rammner B, Woehler A, Mim C, Jahn R, Milosevic I@ (2018) Clathrin coat controls vesicle acidification by blocking vacuolar ATPase activity. eLife 7, doi: 10.7554/eLife.32569
Rostosky CM, Milosevic I (2018) Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration. J Vis Exp 136, doi: 10.3791/57752.
Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Piqué A; Branco Fonseca T; Fernandez CO, Milosevic I, Outeiro TF (2018) Membrane binding is required for the internalization and RAB protein-mediated sorting and processing of α-synuclein in the cell. Acta Neuropathol Commun, 6(1):79
Our work is supported by the German Research Foundation (DFG; Emmy Noether award), Alexander von Humboldt (AvH) Foundation, Schram Foundation, Engelhorn Foundation, SB889 and SFB1190.